专业领域为分子生物学与计算机科学,擅长利用生物信息学方法解决重要的生物学问题。成功开发了多种用于基因模型及调控结构域预测的算法,开发genBlastA和genBlastB软件,分别在Genome Research 和 Bioinformatics杂志上发表并被广泛应用。实际地应用于Bardet-Biedl综合征相关基因的转录调控研究,并利用最新的基因组编辑工具对预测结果进行了验证。随着测序技术的不断发展,研究重心逐渐转向物种基因组进化及变异分析,期间研发出了一套有效的算法,可以用来鉴定引起个体重要基因功能缺陷的杂合突变。参与了肝内胆管癌疾病研究,并发现了多个与疾病相关的显着性突变基因。
1. Gaffney C., Shephard F., Chu J., Baillie D., Rose A.M., Constantin-Teodosiu D., Greenhaff P.L., Szewczyk N.J. (2015). Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle. J Cachexia, Sarcopenia & Muscle 10.1002/jcsm.12040
2. Zou S., Li J., Zhou H., Frech C., Jiang X., Chu J.S.C., Zhao X., Li Y., Li Q., Wang H., Hu J., Zhou F., Zhou W., Wang H., Wu M., Ding C., Chen N., Hu H. (2014). The mutational landscape of intrahepatic cholangiocarcinoma. Nature Communications 5:5696
3. Chu J.S., Chua S.Y., Wong K., Davison A.M., Johnsen R., Baillie D.L., Rose A.M. (2014). High-throughput capturing and characterization of mutations in essential genes of Caenorhabditis elegans. BMC Genomics 15:361. Citation 1
4. Vergara I.A., Tarailo-Graovac M., Frech C., Wang J., Zhang T., Qin Z., She R., Chu J.S.C., Wang K., Chen N. (2013). Loss-of-function mutations in a natural isolate of the nematode Caenorhabditis elegans. BMC Genomics 15(1):255. Citation:4
5. M. Clarke, A.J. Lohan, B. Liu, I. Lagkouvardos, S. Roy, N. Zafar, C. Bertelli, C. Schilde, A. Kianianmomeni, T.R. Bürglin, C. Frech, B. Turcotte, K.O. Kopec, J.M. Synnott, C. Choo, I. Popanov, A. Finkler, C.S.H. Tan, A.P. Hutchins, T. Weinmeier, T. Rattei, J.S.C. Chu, G. Gimenez, M. Irimia, D.J. Rigden, D.A. Fitzpatrick, J. Lorenzo-Morales, A. Bateman, C.-H. Chiu, P. Tang, P. Hegemann, H. Fromm, D. Raoult, G. Greub, D. Miranda-Saavedra, N. Chen, P. Nash, M.L. Ginger, M. Horn, P. Schaap, L. Caler and B. Loftus. (2012). Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of pattern recognition and tyrosine kinase signaling. Genome Biology 14:R11. (Journal impact factor 9.04). Citation:66
6. Uyar B.*, Chu J.S.C.*, Vergara I.A.*, Chua S.Y., Jones M.R., Wong T., Baillie D.L., Chen N. (2012). RNA-seq analysis of C. briggsae transcriptome. Genome Research 22:1567-80. *Co-first author. (High impact journal (13.06) in the field of genomics research). Citations: 14
7. Chu J.S.C., Johnsen R.C., Chua S.Y., Tu D., Dennison M., Marra M., Jones S.J., Baillie D.L., Rose A.M. (2012). Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Genetics 190:1225-33. (A leading journal in the field of genetics). Citation: 6
8. Chu J.S.C., Tarailo-Graovac M., Zhang D., Wang J., Uyar B., Tu D., Trinh J., Baillie D.L., Chen N. (2012). Fine tuning of RFX/DAF-19-regulated target gene expression through binding to multiple sites in Caenorhabditis elegans. Nucleic Acid Research 40:53-64. (Journal impact factor 8.278). Citation 2
9. She R.*, Chu J.S.C.*, Uyar B., Wang J., Wang K., Chen N. (2011). genBlastG: using BLAST searches to build homologous gene models. Bioinformatics 27:2141-3. *Co-First Author. (The leading journal in the field of bioinformatics and computational biology). Citation: 18
10. Chu J.S.C., Baillie D.L., Chen N. (2010). Convergent evolution of RFX transcription factors and ciliary genes predated the origin of metazoans. BMC Evolutionary Biology 10:130. (Journal impact factor 3.52). Citation: 21